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First off, is a necessity: Healing. No matter what strategy you use, healing will buff you up big time. The best healing power in game so far is Life Force. I have it at level 9 and get around 600 regularly, but have gotten critical hits up to 1000. If you're not a member, Molecular Reconstruction at level 15 can easily do 200-300 healing everytime.

Next is your power-hitter attack. You need at least one powerful attack that can deal heavy damage, and preferably at very little Energy cost. I use the Lightning attack in Spears shop, but the Giant attacks and several others work well too.

DoT's or Damage of Time attacks, are important for improving your Damage per turn. I suggest Radiation attacks or Fire attacks, but you can choose your own there.

Then you'll need a support ability that compliments your power hitter, something that gives you that extra edge. Fire, Ice, Radiation, and Lightning. They all have an element alignment. Each element also has a support power that increases the damage done by that type of attack. Pick one of those up. (i.e. Thunderous Rage for Lightning, Frozen Core for Ice, etc.)

Your fifth power is up to you. Some good powers would be Super Speed, which increases your frequency of attacks, or Super Intellect, which raises effects of mental abilities. Personally, I use Uncanny Focus which greatly regenerates energy. If you're not a member, Focus will do more or less the same thing.

Those would be your ideal powers. Good luck!